Geoff Esper has uploaded a video of him eating the 28 inch, 9 pound pizza challenge at Benny Fierro's in Pittsburgh in 6:50, setting the house record and claiming a prize of $500.

May 31, 2019 at 3:12 am by ojrifkin · More posts about:Geoff Esper, Pittsburgh, Pizza Eating Challenges | Permalink * Comments

Comments »

  1. nvuplayer.com said (Comment pending approval)

    October 25, 2025 @ 8:42 am

    Analysis has examined KPV in laboratory models learning anti-inflammatory pathways on the mobile stage.
    In vitro studies have investigated its interaction with inflammatory
    signaling molecules and wound therapeutic mechanisms.
    The peptide enters cells instantly, the place it has been noticed modulating
    inflammatory responses.
    Irritation lies on the root of almost every persistent illness—from
    autoimmune disease and IBS to skin circumstances and even cognitive
    decline. Whereas many interventions goal irritation broadly, KPV
    peptide presents a singular, targeted strategy to immune modulation that
    is each highly effective and gentle on the body. KPV peptide, consisting of the
    amino acids lysine, proline, and valine, is a tripeptide spinoff of the hormone alpha-melanocyte-stimulating hormone (?-MSH).

    Research have demonstrated that PT-141 activates melanocortin receptors MC1R and MC4R, resulting in enhanced libido, whereas it does not
    affect skin tanning. In Distinction To Viagra® and different related medications, it does not act
    upon the vascular system, but instead immediately increases sexual need by way of the nervous system.
    Each stage of the wound healing process reveals totally different characteristics, however most cells specific
    melanocortin 1 receptors (MC1R) which bind alpha-MSH hormone,
    subsequently alpha-MSH analogs corresponding to KPV also bind.
    As A Result Of KPV presents the anti-inflammatory properties of alpha-MSH without being pigment-inducing, it is a good
    candidate for wound therapeutic without changing the characteristics of the
    pores and skin. KPV could additionally be a more effective and focused technique of reducing irritation in IBD by way of its
    effects on TNF-alpha, but without affecting TNF-alpha in different locations of the body.

    KPV additionally reduces NF-kappaB and mitogen-activated
    protein kinase activity. These effects work together with TNF-alpha inhibition to cut
    back inflammatory modifications within the intestine and reduce colonic infiltration.
    However, some commonly reported unwanted facet effects could embrace
    injection web site reactions (such as redness, swelling, or pain), headaches, nausea, fatigue, modifications in appetite, or alterations in hormone ranges.
    These peptides have been specifically developed to extend the manufacturing
    of natural progress hormone. Taking pure progress hormone is
    against the law with no prescription, and is really only prescribed
    to those with a deficiency. It helps tighten the gaps between cells, helps cell recovery, and retains irritation underneath management.
    But while intestine issues like bloating, cramps, or continual an infection take over, day-to-day existence looks like a battle.
    If this sounds familiar, it might be time to look beyond standard treatments.
    One choice catching attention is the KPV peptide,
    a small however highly effective compound that may help gut well being
    in ways that matter.
    The mRNA expression of inflammatory indicators (TNF-?, IL-1?, IL-6, IL-2) was markedly elevated within the LPS group and
    notably decreased in the therapeutic group
    (Supplementary Figures S8A–D). In Addition To, it could possibly suppress the proliferation of cytotoxic T
    cells and the expression of interleukin-2 receptors (Bitton et al., 2012).
    Due To This Fact, we further detected IL-2 protein levels through Western blot, with statistically vital results shown in Supplementary Figures S8E,F.

    KPV works very properly as a topical cream for
    issues such as zits, eczema and psoriasis. In an oral kind, it
    could assist with ulcerative colitis, irritable bowel syndrome, and Crohn’s disease.
    Hereby, the mRNA and protein expression degree of pro-inflammation cytokines (TNF-?,
    IL-1?, IL-6, IL-2) had been detected by real-time PCR and ELISA after remedy of colitis.
    As shown in Figures 5A–D, the colitis group showed the very best mRNA
    expression of TNF-?, IL-1?, IL-6, IL-2, and the mRNA expression of these pro-inflammation cytokines
    had been decreased by KPV and FK506. At the protein degree, outcomes represented that pro-inflammatory cytokines had been lowered
    in the blood serum for all treated mice compared
    to the colitis group, with NPs exhibiting essentially the most pronounced results (Figures 5E–H).

    A Quantity Of analogues of this sequence have additionally
    been examined as nicely as disulfide bridge linked homodimers (eg (CKPV)2 [7]) which yield improvements in the
    peptide’s capacity to suppress NF?B exercise (reviewed [8]).
    Regardless Of these properly documented anti-inflammatory effects, the mechanism of
    KPV motion is poorly understood. Firstly, the KPV residues may individually or
    collectively bind polar or non-polar amino acid sequences
    exposed on the surface of key signalling proteins.
    As the proline residue locations an angle in the KPV peptide, complimentary interactions could happen between one, two or all three residues
    in several attainable orientations. This mannequin can’t, nevertheless, clarify the apparent specificity
    of KPV for the NF?B pathway because the quick peptide sequence would presumably favour
    multiple non-specific targets. An different hypothesis predicts
    that the sequence of KPV will specify its actions to a molecule
    within the NF?B activation pathway. KPV shows the fundamental options of a minimal nuclear
    localisation sequence (NLS).
    It’s a peptide that reduces inflammation within the liver, blood vessels
    and decreases threat of stroke, heart attack, and Alzheimer’s illness.
    It aids in weight reduction by lowering urge for food and cravings, as nicely as reducing fat
    stored within the physique. It is secure for all patients except those with historical past of pancreatitis or thyroid cancer.
    Molecule shaped by combining two or more amino acids (the body has 20 amino acids).

    Sometimes lower than 50 amino acids considered a peptide and greater than a
    hundred thought of a protein in between called polypeptide.
    Insulin, for instance, is a peptide that’s used to
    help the body make the most of glucose (aka sugar).
    Lysine-proline-valine (KPV) is a naturally occurring tripeptide that has shown important promise in attenuating inflammatory responses,
    particularly in colonic cells. This article aims to offer a comprehensive overview of
    the mechanisms, advantages, and research findings associated to KPV, significantly when administered
    orally in nanoparticles. Gastrointestinal research purposes concentrate on inflammatory
    bowel illness models, the place the peptide demonstrates outstanding efficacy in selling mucosal therapeutic and decreasing inflammatory responses.

RSS feed for comments on this post · TrackBack URI

Leave a Comment

Log in | Register | Comments by users who have not logged in will be held for approval